| 10771749 |
Ghittori S, Abatangelo L, Imbriani M: [Biologic monitoring of carbon disulfide: role of glutathione] . G Ital Med Lav Ergon. 1999 Oct-Dec;21(4):341-6.
Work goal is a critical analysis of the possibility of using TTCA as a future marker for next environmental limit values which will be probably fixed to much lower levels. Four metabolites have been identified in the urines of CS2 exposed subjects, exactly: thiocarbamide, 2-mercaptothiazolinone, 2-thiothiazolidine-4-carboxylic acid (TTCA), 2-oxothiazolidine-4-carboxylic acid. TTCA represents about the 6% of absorbed CS2 during occupational exposure. TTCA discovery in the urines of CS2 exposed workers (an heterocyclic compound which develops in vivo through direct reaction between CS2 and Glutatione) allowed a more specific approach to exposure assessment. The end-shift urine TTCA concentration seems to be in strict relationship with CS2 absorbed amount. In 1998 ACGIH maintained the 1997 limit value (TLV-TWA 10 ppm). In the 1997 DFG cut down the limit value in half (MAK 5 ppm), while, until 1996, it accepted the ACGIH value. |
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