| 19526130 |
Zabrodskii PF, Kirichuk VF, Lim VG, Balashov SV, Svistunov AA: Changes in the cytokine profile and reduced function of lymphocyte subpopulations in subacute tetrachloromethane poisoning. Bull Exp Biol Med. 2009 Jan;147(1):52-4.
Experiments on outbred albino rats showed that subacute poisoning with tetrachloromethane in a total dose of 1.0 LD50 appreciably decreased blood concentrations of cytokines (IFN-gamma, IL-2, IL-4, IL-6, IL-10), reduced the IFN-gamma/IL-4 ratio in comparison with the control, and suppressed the immune reactions, which attests to greater damage to Th1 compared to Th2 lymphocytes. |
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