| 20304655 |
Bonifazi EL, Rios-Luci C, Leon LG, Burton G, Padron JM, Misico RI: Antiproliferative activity of synthetic naphthoquinones related to lapachol. Bioorg Med Chem. 2010 Feb 23.
First synthesis of 5-hydroxylapachol.. A series of 5-hydroxy-1,4-naphthoquinones analogues was synthesized from juglone (6) and their antiproliferative activity against a representative panel of six human solid tumor cell lines has been investigated. The 2,5-dihydroxy-3-(3-methylbut-2-enyl) naphthalene-1,4-dione (4) and 2,3-dihydro-5-hydroxy-2-(prop-1-en-2-yl) naphtho [2,3-b] furan-4,9-dione (27) were the most potent antiproliferative agents with GI (50) values of 0.42-8.1 and 0.80-2.2muM, respectively. The results provide insight into the correlation between some structural properties of 5-hydroxynaphthoquinones and their antiproliferative activity. |
6(0,0,1,1) |