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Wang M, Cooley B, Gao M, Miller KD, Sledge GW, Hutchins GD, Zheng QH: Synthesis of new carbon-11 labeled naphthalene-sulfonamides for PET imaging of human CCR8. Appl Radiat Isot. 2008 Oct;66(10):1406-13. Epub 2008 Mar 20.
Carbon-11 labeled naphthalene-sulfonamides, N-(4-(N-(4-[(11) C] methoxyphenyl) sulfamoyl) naphthalene-1-yl) benzamide ([(11) C] 5a), N-(4-(N-(4-[(11) C] methoxyphenyl) sulfamoyl) naphthalene-1-yl)-2-methylbenzam ide ([(11) C] 5b), N-(4-(N-(4-[(11) C] methoxyphenyl) sulfamoyl) naphthalene-1-yl)-3-methylbenzam ide ([(11) C] 5c), N-[(11) C] methyl-N-methyl-4-(4-benzamidonaphthalene-1-sulfonamido) piperidin e-1-carboxamide ([(11) C] 9a) and N-[(11) C] methyl-N-methyl-4-(4-(2-methylbenzamido) naphthalene-1-sulfonamido ) piperidine-1-carboxamide ([(11) C] 9b), have been synthesized as new potential positron emission tomography (PET) agents for imaging of human CCR8. The target tracers were prepared by either O-[(11) C] methylation or N-[(11) C] methylation of their corresponding precursors using [(11) C] CH (3) OTf and isolated by either a simplified solid-phase extraction (SPE) purification procedure or a high pressure liquid chromatography (HPLC) method in 30-50% radiochemical yields decay corrected to end of bombardment (EOB), 20-25 min overall synthesis time, and 74-111 GBq/micromol specific activity at end of synthesis (EOS). |
112(1,2,2,2) |