Protein Information

ID 2636
Name beta hydroxy beta methylglutaryl coenzyme A reductase
Synonyms 3 Hydroxy 3 methylglutaryl CoA reductase; 3 Hydroxy 3 methylglutaryl Coenzyme A reductase; Beta hydroxy beta methyl glutaryl CoA reductase; HMG CoA reductase; HMG Coenzyme A reductase; HMGCR; 3 Hydroxy 3 methylglutaryl Coenzyme A reductases; Beta hydroxy beta methyl glutaryl CoA reductases…

Compound Information

ID 1409
Name silica gel
CAS silica gel

Reference

PubMed Abstract RScore(About this table)
16028969 Kim HJ, Lee DH, Hwang YY, Lee KS, Lee JS: Characterization of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor from Pueraria thunbergiana. J Agric Food Chem. 2005 Jul 27;53(15):5882-8.
This study describes the extraction and characterization of an inhibitor for beta-hydroxy-beta-methylglutaryl (HMG) coenzyme A (CoA) reductase from Pueraria thunbergiana. The maximum HMG-CoA reductase inhibitory activity (IC (50) = 79 microg) was obtained when P. thunbergiana was extracted with 70% ethanol at 30 degrees C for 12 h. After purification of the HMG-CoA reductase inhibitor by means of systematic solvent extraction, silica gel column chromatography, and HPLC, an active fraction with an IC (50) of 0.9 microg (4.25 microM) and a yield of 1.3% was obtained. The purified HMG-CoA reductase inhibitor was identified as daidzein (C (15) H (10) O (4); molecular mass, 254 Da).		 34(0,1,1,4)