| ID | 33 |
|---|---|
| Name | ATPase |
| Synonyms | ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1… |
| ID | 1469 |
|---|---|
| Name | gamma-HCH |
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 7594191 | Anand M, Meera P, Kumar R, Gupta GS, Tripathi O, Srimal RC: Possible role of in the cardiovascular effects of prolonged administration of gamma-HCH (lindane) in rats. J Appl Toxicol. 1995 Jul-Aug;15(4):245-8. Gamma-HCH (lindane) administered for long durations is reported to cause toxic cardiovascular effects. Present study was carried out to assess the changes in cardiovascular activity and cellular homeostatic mechanisms in rats administered 3 mg kg-1 day-1 of gamma-HCH p.o. for 6 weeks. The changes in electrocardiogram were marked by a decrease in R-R interval and the amplitude of the P wave by 53% and 50%, respectively. The amplitude of R and T waves was increased by 65% and 58%, respectively. -45 influx was increased in atrial trabeculae (33%) and in papillary muscle (10%). The plasma concentration was increased (32%) and Ca,K-ATPase activity in heart was decreased (50%). It is suggested on the basis of these findings that cellular homeostatic mechanisms are involved in the cardiovascular effects of gamma-HCH administered chronically in rats. |
1(0,0,0,1) |