| 19070908 |
Kalm M, Lannering B, Bjork-Eriksson T, Blomgren K: Irradiation-induced loss of microglia in the young brain. . J Neuroimmunol. 2009 Jan 3;206(1-2):70-5. Epub 2008 Dec 13.
Irradiation-induced loss of neural stem and progenitor cells may contribute to cognitive deficits. Furthermore, subsequent inflammation inhibits neural progenitor cell differentiation. Here we have characterized the microglia response after a single dose of 8 Gy to the brains of postnatal day 9 or 21 rats. The number of Iba-1-positive microglia increased 6 h after IR but had decreased 7 days later, below control levels, and this decrease was more pronounced in P9 rats. Active caspase-3 and TUNEL staining revealed irradiation-induced microglia death. This age-dependent IR-induced loss of microglia likely affects both the response to IR and further brain development. |
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