| 17928735 |
Egashira N, Hayakawa K, Osajima M, Mishima K, Iwasaki K, Oishi R, Fujiwara M: Involvement of GABA (A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. J Pharmacol Sci. 2007 Oct;105(2):211-4. Epub 2007 Oct 6.
We investigated the involvement of gamma-aminobutyric acid (A) (GABA (A)) receptors in the neuroprotective effect of gamma-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABA (A)-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABA (A) receptors. |
1(0,0,0,1) |