| 8242434 |
Ito S, Tateno C, Tanaka M, Yoshitake A: Effects of fenvalerate and esfenvalerate on hepatic gap junctional intercellular communication in rats. Cell Biol Toxicol. 1993 Apr-Jun;9(2):189-96.
Effects of in vivo exposure with fenvalerate, esfenvalerate and DDT on hepatic gap junctional intercellular communication (GJIC) in Sprague-Dawley (SD) rats were examined by in vivo/in vitro dye-transfer assay and by immunohistochemical staining of connexin 32 (Cx32, major liver gap junction protein). Fenvalerate (75 mg/kg/day), esfenvalerate (25 mg/kg/day), DDT (50 mg/kg/day) and corn oil (vehicle control, 5 ml/kg/day) were administered orally once a day. Animals were killed at weeks 1, 2, 4 and 6 after starting the experiment. In the fenvalerate- and esfenvalerate-groups, no compound-related changes in GJIC and Cx32 expression were observed. On the contrary, in the DDT-group, average sizes of the dye spread after injection of Lucifer Yellow decreased at weeks 1, 2 and 4, and the area per GJ spot shown by Cx32-immunohistochemical staining decreased at weeks 4 and 6. It is concluded that neither fenvalerate nor esfenvalerate inhibits hepatic GJIC with in vivo exposure. |
81(1,1,1,1) |