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Carrillo-Lopez N, Fernandez-Martin JL, Cannata-Andia JB: [The role of calcium, calcitriol and their receptors in parathyroid regulation]. Nefrologia. 2009;29(2):103-8. doi: 10.3265/Nefrologia.2009.29.2.5154.en.full.
The mechanism of regulation of Parathyroid hormone (PTH) is complex, and diverse factors are involved: the fundamental ones are calcium, calcitriol and phosphorus. Calcium and calcitriol's mechanism of action takes place through its specific receptors, the calcium-sensing receptor (CaR) and the Vitamin D Receptor (VDR). These two factors have an effect not only on its specific receptors, but also they can modify the other receptor in a positive manner, promoting its actions and demonstrating a cooperative effect between the two. Along with calcium and calcitriol, drugs used in the treatment of Chronic Kidney Disease Mineral Bone Disorders (CKD-MBD) also act directly or indirectly on CaR and VDR and therefore are also responsible for the regulation of the parathyroid gland. |
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