| 3930163 |
Rounds S, Farber HW, Hill NS, O'Brien RF: Effects of endothelial cell injury on pulmonary vascular reactivity. Chest. 1985 Oct;88(4 Suppl):213S-216S.
Using the thiocarbamide model of acute lung injury in rats, we found that alpha-naphthylthiourea (ANTU) caused lung endothelial cell injury, as evidenced by increased permeability edema and decreased angiotensin I conversion. These effects were associated with enhanced pulmonary vascular reactivity. Recurrent ANTU lung injury caused pulmonary hypertension. The water-soluble thiocarbamide thiourea caused cultured vascular endothelial cells to release neutrophil chemoattractant activity. We speculate that endothelial cell injury may modulate the function of vascular smooth muscle and blood leukocytes. |
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