| 19837049 |
Rosseto R, Hajdu J: Synthesis of oligo (ethylene glycol) substituted phosphatidylcholines: secretory PLA2-targeted precursors of NSAID prodrugs. Chem Phys Lipids. 2010 Jan;163(1):110-6. Epub .
A series of new phosphatidylcholine analogues with structurally modified sn-2-substituents have been prepared. The synthetic compounds include oligo (ethylene glycol) derivatives with chain-terminal pharmacophores that upon catalytic hydrolysis by phospholipase A (2) yielded a series of oligo (ethylene glycol)-conjugates of the respective drugs. The approach here outlined may open a new way to employ OEG derivatives of phospholipids for therapeutic applications as secretory PLA (2)-targeted precursors of prodrugs. |
32(0,1,1,2) |