| 20225892 |
Gou PF, Zhu WP, Shen ZQ: Synthesis, Self-Assembly, and Drug-Loading Capacity of Well-Defined Cyclodextrin-Centered Drug-Conjugated Amphiphilic A (14) B (7) Miktoarm Star Copolymers Based on Poly (epsilon-caprolactone) and Poly (ethylene glycol). Biomacromolecules. 2010 Mar 12.
Novel drug-conjugated amphiphilic A (14) B (7) miktoarm star copolymers composed of 14 poly (epsilon-caprolactone) (PCL) arms and 7 poly (ethylene glycol) (PEG) arms with beta-cyclodextrin (beta-CD) as core moiety were synthesized by the combination of controlled ring-opening polymerization (CROP) and "click" chemistry. (1) H NMR, FT-IR, and SEC-MALLS analyses confirmed the well-defined A (14) B (7) miktoarm star architecture. These amphiphilic miktoarm star copolymers could self-assemble into multimorphological aggregates in aqueous solution, which were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Moreover, the drug-loading efficiency and drug-encapsulation efficiency of the drug-conjugated miktoarm star copolymers were higher than those of the corresponding non-drug-conjugated miktoarm star copolymers. |
81(1,1,1,1) |