| 20200707 |
Barry NP, Edafe F, Dyson PJ, Therrien B: Anticancer activity of osmium metalla-rectangles. Dalton Trans. 2010 Mar 21;39(11):2816-20. Epub 2010 Feb 4.
A series of cationic metalla-rectangles of the general formula [(p-cymene)(4) Os (4)(OO [intersection] OO)(2)(N [intersection] N)(2)](4+) have been obtained in methanol from the dinuclear arene osmium precursors [(p-cymene)(2) Os (2)(OO [intersection] OO)(2) Cl (2)] (OO [intersection] OO = 2,5-dioxydo-1,4-benzoquinonato (dhbq), 2,5-dichloro-1,4-benzoquinonato (dcbq)) by reaction with bipyridine linkers (N [intersection] N = 4,4'-bipyridine, 1,2-bis (4-pyridyl) ethylene) in the presence of AgCF (3) SO (3). All complexes were isolated as triflate salts and characterised by NMR, IR and UV-visible spectroscopy. The cytotoxicities of the dinuclear and tetranuclear osmium complexes were established using ovarian A2780 cancer cell lines. The most active metalla-rectangle, [(p-cymene)(4) Os (4)(dhbq)(2)(4,4'-bipyridine)(2)](4+), shows an IC (50) value of 5.7 microM (comparable to cisplatin) against A2780 cancer cells and 7.5 microM against the cisplatin resistant A2780cisR cells. |
6(0,0,1,1) |