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Thirupathi P, Kim SS: InBr3: a versatile catalyst for the different types of Friedel-Crafts reactions. J Org Chem. 2009 Oct 16;74(20):7755-61.
Mild and efficient InBr (3)-catalyzed Friedel-Crafts alkylation of heteroaromatic or electron-rich aromatic compounds with alpha-amido sulfones at room temperature in CH (2) Cl (2) has been developed. The products undergo further Friedel-Crafts alkylation with heteroaromatic or electron-rich aromatic compounds leading to unsymmetrical or bis-symmetrical triaryl methanes in good yield. Alpha-amido sulfones are employed for the synthesis of the unsymmetrical and bis-symmetrical triaryl methanes. The use of mild reaction condition, low catalytic loading, and high yield are the advantages of the present procedures. |
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