| 4023425 |
Sugiyama S, Igarashi T, Ueno K, Satoh T, Kitagawa H: Increase in anti-carboxylesterase action of organophosphorothioates by nicotinamide adenine dinucleotide (NAD) in vitro. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):455-8.
The purpose of the present study was to investigate the relationship between chemical structure of organophosphorus insecticides and potentiation of anti-carboxylesterase (CEase) action of these insecticides by NAD in vitro (NAD-effect). Experiments using with three organophosphorothioates having ethoxy group except for diazinon exhibited greater NAD-effect than those having methoxy ones such as methylparathion and fenitrothion. In contrast, none of five organophosphates tested showed NAD-effect. And, 3-acetylpyridine adenine dinucleotide (Ac-py AD) among four derivertives of NAD was also found to have NAD-effect. These results suggested that P = S group in the molecule of organophosphorus insecticides was needed to occur NAD-effect. In addition, the extent of NAD-effect using acetylcholinesterase (AChE) was lesser than that of CEase, therefore, a higher susceptibility of liver microsomal CEase to organophosphorus insecticides may be explained, at least inpart, by NAD-effect. |
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