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Debnath SC, Kundu A, Das SK, Mandal TK, Bhattacharyya A, Choudhury A, Chakraborty AK: Toxicokinetics, recovery, and metabolism of metamitron in goat. J Agric Food Chem. 2003 Sep 24;51(20):5977-84.
Toxicokinetic behavior and metabolism studies of metamitron and its effect on the cytochrome P (450) content of liver microsomal pellet were carried out in black Bengal goats after a single oral administration at 278 mg kg (-1) and consecutive oral administration of 30 mg kg (-1) for 7 days. Metamitron was detected in the blood sample at 0.08 h (12.0 +/- 0.87 microg mL (-1)), maximum at 4 h (84.3 +/- 8.60 microg mL (-1)) and minimum (14.6 +/- 1.67 microg mL (-1)) at 36 h blood sample after a single oral administration. The absorption rate constant was 0.69 +/- 0.09 h (-1). The Vd (area) (2.00 +/- 0.08 L kg (-1)) and t (1/2) beta (8.98 +/- 0.70 h) values suggested wide distribution and long persistence of the compound in the body. The values of T approximately B (0.80 +/- 0.04), F (c) (0.55 +/- 0.01), Cl (B) (0.15 +/- 0.00 L kg (-1) h (-1)), and K (21) (0.41 +/- 0.03 h (-1)) suggested that metamitron retained in the blood compared to that in the tissue. Maximum concentration of metamitron residue was found in the adrenal gland followed by bile on day 4 of single oral administration. The higher Cl (R) compared to Cl (H) value indicated the excretion of the major portion (34-40%) through urine compared to feces (20-26%). Maximum concentrations of metamitron and its metabolite, deaminometamitron, were excreted through urine and feces at 48 and 24 h samples, respectively. The recovery of metamitron including its metabolite in terms of parent compound varied from 69.3 to 80.1%, of which contribution of metabolite in terms of parent compound varied from 53.1 to 63.0%. Repeated oral administration of metamitron at 30 mg kg (-1) for 7 days caused induction of the cytochrome P (450) content of liver microsomal pellet of goat, suggesting oxidative deamination of metamitron. |
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