| 19473841 |
Ohno I, Tomizawa M, Durkin KA, Casida JE, Kagabu S: Bis-neonicotinoid insecticides: Observed and predicted binding interactions with the nicotinic receptor. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3449-52. Epub 2009 May 9.
The bis-pharmacophore approach applied to neonicotinoid insecticides reveals high binding affinity for heptamethylene bis-N (3),N (3')-imidacloprid fitting a nicotinic acetylcholine receptor model wherein the chloropyridine moieties contact loops E and F and the alkylene linker bridges these two distant domains. |
31(0,1,1,1) |