Protein Information

ID 3969
Name vascular endothelial growth factor C
Synonyms Flt4 ligand; VRP; Flt4 L; Flt4L; VEGF C; VEGFC; Vascular endothelial growth factor C; Vascular endothelial growth factor C precursor…

Compound Information

ID 955
Name TCA
CAS 2,2,2-trichloroacetic acid

Reference

PubMed Abstract RScore(About this table)
12898752 Hua C, Pan J, Wen Y: [The effect of gene transfection of vascular endothelial growth factor-C on the metastasis ability of Tca8113]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2003 Jun;21(3):171-3.
OBJECTIVE: To study the role that vascular endothelial growth factor-C plays in the lymph node metastasis of the squamous cell carcinoma (SCC) of tongue. METHODS: An established VEGF-C transfected Tca8113 cell strain (VcTca) was heterotransplanted into BALB/C nude mice subcutaneously. The expression of VEGF-C and VEGFR-3 was detected. The property of tumorigenesis and metastasis of the transfected cell was investigated. RESULTS: Jugular lymphatic metastases developed in 4/6 mice of VcTca group in 6 weeks after transplantation, while no lymph node metastasis was found in mice with tumors of non-transfected Tca8113 cell (Tca) and mock transfected cell (pDTca) at the same time. There was no difference in tumor weight among VcTca, pDTca and Tca (P > 0.05). CONCLUSION: It is suggested that VEGF-C could promote lymph node metastatic ability of Tca8113 cell, and could be utilized as a target of new regimen in prevention and treatment for lymphatic metastasis of oral carcinomas.
5(0,0,0,5)