| 17503247 |
Gil HW, Hong JR, Park JH, Seo YS, Yang JO, Lee EY, Hong SY: Plasma surfactant D in patients following acute paraquat intoxication. Clin Toxicol. 2007 Jun-Aug;45(5):463-7.
Free radical-induced lung injury is a major problem that occurs because of paraquat intoxication. Serum surfactant protein D (SP-D) reflects the severity of various lung diseases. The purpose of this study is to investigate the changes in plasma SP-D concentrations and to correlate disease severity with SP-D concentrations in patients with acute paraqaut intoxication. Twelve paraquat-intoxicated patients participated in this study. Their paraquat exposure was assessed by their plasma's paraquat level. Serial plasma SP-Ds were measured by ELISA. SP-D was decreased two and three days after the initial measurement within 2 to 72 hours of ingestion. There was no difference in initial SP-D levels between survivors and non-survivors. The SP-D test revealed a significant positive correlation between the SP-D level and PaO (2) (r = 0.384, p = 0.003, N = 57). SP-D did not predict the likelihood of survival, but it was positively correlated with PaO (2). This finding suggests that low concentrations of plasma SP-D could reflect hypoxia due to free radical-induced injury. |
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