| 17535659 |
Jian XD, Sui H, Chu ZH, Zhang ZW, Kan BT, Zhang L, Zhang HT: [Changes of serum cytokine caused by acute paraquat poisoning] . Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007 Apr;25(4):230-2.
OBJECTIVE: To observe the change of cytokine interleukin IL-1 beta, IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha) occurred in acute paraquat (PQ) poisoning rats and to investigate the mechanism of acute lung injury caused by paraquat (PQ) poisoning. METHODS: All 72 healthy adult Wistar rats were random assigned into normal control groups, paraquat high dose group (120 mg/kg), paraquat middle dose (60 mg/kg) group, paraquat low dose group (30 mg/kg). Three observing periods of time included 8, 24, 72 h and the standards of TNF-alpha, IL-1 beta, IL-6, IL-10 were determined. RESULTS: Every index of the PQ group was significantly higher than that in the NS group at the same period of time (P <0.05 or P <0.01). In the 72 h group, the high dose group was significantly higher than the middle and low dose group (P <0.05), and there was no significantly difference between the middle and low dose group (P> 0.05). For the comparison of index in the same dose group, the group of 72 h was much higher than 8 h group and 24 h group (P <0.05), and there was no difference between the 8h group and 24 h group (P> 0.05). CONCLUSION: The cytokine may play an important role in paraquat-induced acute lung tissue injury. |
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