Protein Information

ID 88
Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

ID 1325
Name azadirachtin
CAS

Reference

PubMed Abstract RScore(About this table)
17765967 Senthil Nathan S, Young Choi M, Yul Seo H, Hoon Paik C, Kalaivani K, Duk Kim J: Effect of azadirachtin on acetylcholinesterase (AChE) activity and histology of the brown planthopper Nilaparvata lugens (Stal). Ecotoxicol Environ Saf. 2008 Jun;70(2):244-50. Epub 2007 Sep 4.
The effect of azadirachtin (AZA), a tetranortriterpene from neem, on the mortality, acetylcholinesterase (AChE) activity, and the development of the ovaries of female brown planthopper (BPH), Nilaparvata lugens (Stal) was tested in laboratory experiments. The lethal concentrations were determined and applied topically to the adult female BPH (LC (50)=0.47 ppm and LC (90)=0.96 ppm). The treated insects exhibited toxic symptoms with a dose-dependent mortality. The LC (50) concentrations were tested against AChE activity of the BPH. The results indicate that AZA significantly inhibits the activity of AChE only at the high dose (P <.0001) compared with control. Adult females that were exposed to AZA showed a significant reduction in weight (23%, 40%, and 64% for 0.1, 0.25, and 0.5 ppm, respectively). Fecundity was also significantly reduced in AZA treatments compared to the control. Histological study of ovary sections revealed abnormalities in follicular epithelial cells due to AZA treatment.
13(0,0,2,3)