| 17137383 |
Goossen LJ, Blanchot M, Brinkmann C, Goossen K, Karch R, Rivas-Nass A: Ru-catalyzed stereoselective addition of imides to alkynes. J Org Chem. 2006 Dec 8;71(25):9506-9.
A catalyst system formed in situ from bis (2-methylallyl) cycloocta-1,5-dieneruthenium (II) ((cod) Ru [met] 2), a phosphine, and scandium (III) trifluoromethanesulfonate (Sc (OTf) 3) was found to efficiently catalyze the anti-Markovnikov addition of imides to terminal alkynes, allowing mild and atom-economic synthesis of enimides. Depending on the phosphine employed, both the (E)- and the (Z)-isomer can be accessed stereoselectively. |
31(0,1,1,1) |