| 19139745 |
Adler A, Afek A, Levy Y, Keren G, George J: Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis. Nat Clin Pract Cardiovasc Med. 2009 Mar;6(3):215-8. Epub 2009 Jan 13.
BACKGROUND: A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina. INVESTIGATIONS: Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG. DIAGNOSIS: Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel. MANAGEMENT: The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0. |
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