| 6710541 |
Gupta M, Bagchi GK, Gupta SD, Sasmal D, Chatterjee T, Dey SN: Changes of acetylcholine, catecholamines and amino acid in mice brain following treatment with Nuvacron and Furadan. Toxicology. 1984 Mar;30(2):171-5.
The effects of multiple intraperitoneal doses of Nuvacron (0.8 mg/kg) or Furadan (0.25 mg/kg) on the concentrations of brain neurotransmitters in mice were studied. The following were measured: acetylcholine, acetylcholinesterase, gamma-aminobutyric acid, epinephrine, norepinephrine, dopamine and 5-hydroxytryptamine. These pesticides caused a significant decrease in acetylcholinesterase activity and a significant increase in acetylcholine, gamma-amino-butyric acid, epinephrine, norepinephrine, dopamine and 5-hydroxy tryptamine concentrations. The increased concentrations of the neurotransmitters in mouse brain might be associated with CNS depressant action induced by the insecticides. |
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