| 11425550 |
Nortey SO, Baxter EW, Codd EE, Zhang SP, Reitz AB: Piperazinyl benzamidines: synthesis and affinity for the delta opioid receptor. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1741-3.
Piperazinyl benzamidines were prepared and found to bind to the rat delta (delta) opioid receptor. The most active compounds had a N,N-diethylcarboxamido group and a N-benzyl piperazine. The most potent among these was N,N-diethyl-4-[4-(phenylmethyl)-1-piperazinyl][2-(trifluoromethyl) phenyl] i minomethyl] benzamide (27) with a 1.22nM K (i) for the rat delta opioid receptor and ca. 1000 x selectivity relative to the mu opioid subtype. |
3(0,0,0,3) |