| 11338664 |
Laszlovszky I, Acs T, Kiss B, Domany G: Substituted phenoxyalkylpiperazines as dopamine D3 receptor ligands. . Pharmazie. 2001 Apr;56(4):287-9.
A novel series of potential antipsychotic agents were prepared by combination of condensed heterocycles containing bridgehead nitrogen with (2-methoxyphenyl) piperazine using phenoxyalkyl spacer of variable length. The affinity of the compounds was determined at rat cloned D3 and rat D2, 5-HT1A receptors by an vitro receptor binding assay. The D3 selectivity of the compounds was calculated from the Ki values. |
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