Protein Information

ID 3888
Name melanocortin 4 receptor
Synonyms MC4 R; MC4R; MCR receptor; Melanocortin 4 receptor; Melanocortin receptor 4; MCR receptors; Melanocortin 4 receptors; Melanocortin receptor 4s

Compound Information

ID 1819
Name piperazine
CAS piperazine

Reference

PubMed Abstract RScore(About this table)
16824757 Chen CW, Tran JA, Jiang W, Tucci FC, Arellano M, Wen J, Fleck BA, Marinkovic D, White NS, Pontillo J, Saunders J, Madan A, Foster AC, Chen C: Propionylpiperazines as human melanocortin-4 receptor ligands. . Bioorg Med Chem Lett. 2006 Sep 15;16(18):4800-3. Epub 2006 Jul 7.
A series of alpha-benzylpropionylpiperazines were synthesized and tested as antagonists of the melanocortin-4 receptor. In addition to its high potency and selectivity, R-11a had desirable pharmacokinetic properties including high brain penetration in mice.		 2(0,0,0,2)