GTPase

General Information (Source: NCBI Gene,UniProt)

Text mining Term GTPase
UniProt ID MNME_ECOLI
Name tRNA modification GTPase MnmE
Gene Names mnmE
Taxonomy Escherichia coli K-12

General annotation

Function Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34.
Subcellular location Cytoplasm. Note=Partially associated with the inner membrane.

Gene Ontology

GO:0005515 protein binding MF
GO:0005625 soluble fraction CC
GO:0003924 GTPase activity MF
GO:0005624 membrane fraction CC
GO:0005737 cytoplasm CC
GO:0006805 xenobiotic metabolic process BP
GO:0005525 GTP binding MF
GO:0030488 tRNA methylation BP
GO:0046872 metal ion binding MF
GO:0009268 response to pH BP

Sequence

>gi|16131574|ref|NP_418162.1| GTPase [Escherichia coli str. K-12 substr. MG1655]
MSDNDTIVAQATPPGRGGVGILRISGFKAREVAETVLGKLPKPRYADYLPFKDADGSVLDQGIALWFPGP
NSFTGEDVLELQGHGGPVILDLLLKRILTIPGLRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQA
ARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNDVIADLDAVRAEARQG
SLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREASDE
VERIGIERAWQEIEQADRVLFMVDGTTTDAVDPAEIWPEFIARLPAKLPITVVRNKADITGETLGMSEVN
GHALIRLSARTGEGVDVLRNHLKQSMGFDTNMEGGFLARRRHLQALEQAAEHLQQGKAQLLGAWAGELLA
EELRLAQQNLSEITGEFTSDDLLGRIFSSFCIGK

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Database Cross Reference

Ensembl Gene
UniGene
PDB 2GJ9
1RFL
2GJA
2GJ8
RefSeq NP_418162.1
Pfam PF10396
PF01926