| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0050661 | NADP binding | MF |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RE7 1DRE 1RX4 1JOM 2DRC 7DFR 1DRA 1RX9 3OCH 5DFR 3DRC 1RB3 1RX3 1RB2 1DRH 1DYI 1DHI 3DAU 1DRB 1RF7 1RA8 1RA2 1RX5 1RH3 1RA3 1RG7 1RA1 1RX1 3KFY 4DFR 2ANO 1DYJ 1RX2 1RX6 3K74 1RA9 1RX8 1DYH 1RC4 2D0K 2ANQ 1JOL 1TDR 1RD7 2INQ 6DFR 1DHJ 1RX7 3QL3 1DDR 1DDS |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |