dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0031427	response to methotrexate	BP
GO:0046677	response to antibiotic	BP
GO:0042493	response to drug	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0050661	NADP binding	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RX2 1TDR 1RX3 1RE7 7DFR 1RA9 1RX9 1DYH 1RA2 2INQ 1RB2 1RX6 1RF7 3OCH 3QL3 1RX5 1RA1 1RX7 1DHI 3DRC 1RX4 1DDR 1RA3 1RA8 4DFR 1RB3 2D0K 1DHJ 1DYJ 1RD7 1JOM 2ANQ 1RG7 2ANO 1DDS 6DFR 1JOL 1DRA 3DAU 5DFR 1DRE 1RX8 3KFY 1RX1 3K74 1DYI 1DRB 1DRH 1RC4 2DRC 1RH3
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference