dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0031427	response to methotrexate	BP
GO:0006730	one-carbon metabolic process	BP
GO:0046677	response to antibiotic	BP
GO:0050661	NADP binding	MF
GO:0004146	dihydrofolate reductase activity	MF
GO:0009165	nucleotide biosynthetic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0042493	response to drug	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1DYJ 1RX9 1RG7 1RA9 1RX4 2ANQ 1RA8 1DHJ 1RH3 1DYH 1JOM 1DHI 1RA3 1RX2 1RX6 3QL3 1RX8 1RA1 3DRC 3DAU 2INQ 1RA2 1DYI 1RB3 3OCH 5DFR 1RB2 2D0K 6DFR 1DDS 1RX7 1DRA 1DDR 1DRB 1TDR 2ANO 1DRH 4DFR 1RD7 1JOL 1DRE 2DRC 1RC4 1RX1 3KFY 1RF7 1RX5 7DFR 1RX3 1RE7 3K74
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference