| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0046677 | response to antibiotic | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0042493 | response to drug | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
2D0K 1DYI 1TDR 2DRC 3KFY 1RF7 1RC4 1JOL 1RX5 6DFR 1DRB 2INQ 1RX6 1RX9 1RX7 1RX1 3OCH 2ANQ 1RA2 1RX4 1DHI 3QL3 1DRH 1DYH 1RA8 5DFR 3DRC 1RE7 2ANO 4DFR 1RD7 1DDS 1RH3 1DDR 1DRE 1DYJ 1RX8 1RX3 1RB3 1RA1 7DFR 1RG7 1JOM 3K74 1RB2 1DHJ 1RX2 1RA9 1RA3 1DRA 3DAU |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |