Acetylcholinesterase

General Information (Source: NCBI Gene,UniProt)

Text mining Term Acetylcholinesterase
UniProt ID ACES_RAT
Name AChE
Acetylcholinesterase
Gene Names Ache
Taxonomy Rattus norvegicus

General annotation

Function Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
Subcellular location Cell junction, synapse. Secreted. Cell membrane; Peripheral membrane protein (By similarity). Isoform H: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side.

Gene Ontology

GO:0019695 choline metabolic process BP
GO:0005788 endoplasmic reticulum lumen CC
GO:0005794 Golgi apparatus CC
GO:0045211 postsynaptic membrane CC
GO:0005635 nuclear envelope CC
GO:0050775 positive regulation of dendrite morphogenesis BP
GO:0033265 choline binding MF
GO:0030054 cell junction CC
GO:0030425 dendrite CC
GO:0042166 acetylcholine binding MF
GO:0005791 rough endoplasmic reticulum CC
GO:0004091 carboxylesterase activity MF
GO:0050772 positive regulation of axonogenesis BP
GO:0031225 anchored to membrane CC
GO:0031594 neuromuscular junction CC
GO:0006581 acetylcholine catabolic process BP
GO:0009986 cell surface CC
GO:0042734 presynaptic membrane CC
GO:0030424 axon CC
GO:0048471 perinuclear region of cytoplasm CC
GO:0043025 neuronal cell body CC
GO:0005615 extracellular space CC
GO:0007416 synapse assembly BP
GO:0005886 plasma membrane CC
GO:0003990 acetylcholinesterase activity MF
GO:0007271 synaptic transmission, cholinergic BP

Sequence

>gi|25282401|ref|NP_742006.1| acetylcholinesterase precursor [Rattus norvegicus]
MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAE
PPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPT
SPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLA
LQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRAT
LLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTG
DFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPE
DPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPL
DPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQYVSLNLKPLEVRRGLRAQTC
AFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQERCSDL

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.105879
PDB
RefSeq NP_742006.1
Pfam PF00135
PF08674