calmodulin

General Information (Source: NCBI Gene,UniProt)

Text mining Term calmodulin
UniProt ID CALM_MOUSE
Name Calmodulin
CaM
Gene Names Calm3
Taxonomy Mus musculus

General annotation

Function Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).
Subcellular location Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules (By similarity).

Gene Ontology

GO:0000922 spindle pole CC

Sequence

>gi|6753244|ref|NP_033920.1| calmodulin [Mus musculus]
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFL
TMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYE
EFVQMMTAK

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Database Cross Reference

Ensembl Gene ENSMUST00000110082
ENSMUST00000040440
ENSMUST00000019514
UniGene Mm.329243
Mm.285993
Mm.288630
PDB 2IX7
2DFS
RefSeq NP_033920.1
NP_031615.1
NP_031616.1
Pfam PF00036