calmodulin

General Information (Source: NCBI Gene,UniProt)

Text mining Term	calmodulin
UniProt ID	CALM_RAT
Name	CaM Calmodulin
Gene Names	Calm3
Taxonomy	Rattus norvegicus

General annotation

Function	Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+), AND MASS SPECTROMETRY. Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).
Subcellular location	Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules (By similarity).

Function

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+), AND MASS SPECTROMETRY. Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).

Subcellular location

Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules (By similarity).

Gene Ontology

GO:0000922	spindle pole	CC
GO:0005246	calcium channel regulator activity	MF
GO:0043548	phosphatidylinositol 3-kinase binding	MF
GO:0048306	calcium-dependent protein binding	MF

Sequence

>gi|14010863|ref|NP_114175.1| calmodulin [Rattus norvegicus]
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFL
TMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYE
EFVQMMTAK

Database Cross Reference

Ensembl Gene	ENSRNOT00000022603 ENSRNOT00000064679
UniGene	Rn.4166 Rn.2892 Rn.5968 Rn.216430
PDB	3EKJ 3EK4 3EK7 2YGG 1QX7 3EK8 3EKH 3EVR 1G4Y 3EVU 2PQ3 3CLN 3IFK 1QX5 3B32 3BXL 2HQW 3EVV 1NIW 3BXK
RefSeq	NP_059022.1 NP_036650.1 NP_114175.1
Pfam	PF00036

PTID

calmodulin

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference