caspase 3

General Information (Source: NCBI Gene,UniProt)

Text mining Term caspase 3
UniProt ID CASP3_MOUSE
Name SCA-1
Cysteine protease CPP32
Caspase-3 subunit p12
SREBP cleavage activity 1
Protein Yama
LICE
Caspase-3
CPP-32
Apopain
Caspase-3 subunit p17
CASP-3
Gene Names Casp3
Synonyms:Cpp32
Taxonomy Mus musculus

General annotation

Function Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
Subcellular location Cytoplasm.

Gene Ontology

GO:0005515 protein binding MF
GO:0043525 positive regulation of neuron apoptosis BP
GO:0004861 cyclin-dependent protein kinase inhibitor activity MF
GO:0001782 B cell homeostasis BP
GO:0004197 cysteine-type endopeptidase activity MF
GO:0045165 cell fate commitment BP
GO:0007605 sensory perception of sound BP
GO:0045736 negative regulation of cyclin-dependent protein kinase activity BP
GO:0043029 T cell homeostasis BP
GO:0030889 negative regulation of B cell proliferation BP
GO:0016485 protein processing BP
GO:0001836 release of cytochrome c from mitochondria BP
GO:0030216 keratinocyte differentiation BP
GO:0004190 aspartic-type endopeptidase activity MF
GO:0046007 negative regulation of activated T cell proliferation BP
GO:0006309 DNA fragmentation involved in apoptotic nuclear change BP
GO:0009611 response to wounding BP
GO:0006974 response to DNA damage stimulus BP
GO:0007507 heart development BP
GO:0008631 induction of apoptosis by oxidative stress BP
GO:0009411 response to UV BP
GO:0051402 neuron apoptosis BP
GO:0008625 induction of apoptosis via death domain receptors BP

Sequence

>gi|6753284|ref|NP_033940.1| caspase-3 [Mus musculus]
MENNKTSVDSKSINNFEVKTIHGSKSVDSGIYLDSSYKMDYPEMGICIIINNKNFHKSTGMSSRSGTDVD
AANLRETFMGLKYQVRNKNDLTREDILELMDSVSKEDHSKRSSFVCVILSHGDEGVIYGTNGPVELKKLT
SFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDEEMACQKIPVEADFLYAYSTAPGYYSWRNSK
DGSWFIQSLCSMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELYFYH

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000093517
UniGene Mm.34405
PDB
RefSeq NP_033940.1
Pfam PF00656