Text mining Term | cis 4 |
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UniProt ID | SOCS6_MOUSE |
Name |
SOCS-6 SOCS-4 Suppressor of cytokine signaling 4 CIS-4 Cytokine-inducible SH2 protein 4 Suppressor of cytokine signaling 6 |
Gene Names |
Socs6
|
Taxonomy | Mus musculus |
Function |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity). |
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Subcellular location |
GO:0040008 | regulation of growth | BP |
GO:0009968 | negative regulation of signal transduction | BP |
GO:0035556 | intracellular signal transduction | BP |
GO:0005515 | protein binding | MF |
>gi|31543755|ref|NP_061291.2| suppressor of cytokine signaling 6 [Mus musculus] MKKISLKTFRKSFNLSKSKDETEFMVVQPQSLAGDFVKDDSLFGSCYGKDMASCDIGSEDEKGKNRSKSE SLMGTLKRRLSAKQKTKGKGGTASTDEDTFSSASAPGGLKDVRAPRPIRSTSLRSHHYSPTPWPLRPTSS EETCIKMEMRVKALVHAASPGPVNGVRKDLRELQPRELRDLQPEPRPESRCSPSSPGDLSLHLEEHVPVV IGLMSQDYLQYTVPLDDGMCPLEGPRSCCLDTSSPMEVSAVPLPGASGAFSEDDSHVDQDLVVGPEILVD SSVNNLLIGTTGVMLQSPRGGHDDAPPLSPLLPPMQNNPIQRNFSGLSGPDLHMAESVRCHLNFDPNSAP GVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSF RSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVS RFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY |
Ensembl Gene |
ENSMUST00000125362 ENSMUST00000070116 ENSMUST00000123826 |
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UniGene |
Mm.476577 Mm.91920 |
PDB | |
RefSeq |
NP_061291.2 |
Pfam |
PF00017 PF07525 |