glutathione S transferase

General Information (Source: NCBI Gene,UniProt)

Text mining Term glutathione S transferase
UniProt ID HPGDS_RAT
Name H-PGDS
Prostaglandin-H2 D-isomerase
Glutathione S-transferase
Hematopoietic prostaglandin D synthase
GST class-sigma
Glutathione-dependent PGD synthase
Glutathione-requiring prostaglandin D synthase
Gene Names Hpgds
Taxonomy Rattus norvegicus

General annotation

Function Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
Subcellular location Cytoplasm.

Gene Ontology

GO:0005509 calcium ion binding MF
GO:0005737 cytoplasm CC
GO:0001516 prostaglandin biosynthetic process BP
GO:0004667 prostaglandin-D synthase activity MF
GO:0000287 magnesium ion binding MF
GO:0004364 glutathione transferase activity MF

Sequence

>gi|13928888|ref|NP_113832.1| hematopoietic prostaglandin D synthase [Rattus norvegicus]
MPNYKLLYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPKIKPTLPFGKIPVLEVEGLTLHQSLAIARY
LTKNTDLAGKTELEQCQVDAVVDTLDDFMSLFPWAEENQDLKERTFNDLLTRQAPHLLKDLDTYLGDKEW
FIGNYVTWADFYWDICSTTLLVLKPDLLGIYPRLVSLRNKVQAIPAISAWILKRPQTKL

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Database Cross Reference

Ensembl Gene ENSRNOT00000008826
UniGene Rn.10837
PDB 1PD2
RefSeq NP_113832.1
Pfam PF02798
PF00043