alpha 1A adrenoceptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term alpha 1A adrenoceptor
UniProt ID ADA1A_MOUSE
Name Alpha-1A adrenoceptor
Alpha-1C adrenergic receptor
Alpha-1A adrenoreceptor
Alpha-1A adrenergic receptor
Gene Names Adra1a
Synonyms:Adra1c
Taxonomy Mus musculus

General annotation

Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0016021 integral to membrane CC
GO:0016049 cell growth BP
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure BP
GO:0035265 organ growth BP
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure BP
GO:0007512 adult heart development BP
GO:0005624 membrane fraction CC
GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger BP
GO:0004937 alpha1-adrenergic receptor activity MF
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine BP
GO:0043410 positive regulation of MAPKKK cascade BP
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine BP
GO:0005886 plasma membrane CC

Sequence

>gi|31542114|ref|NP_038489.2| alpha-1A adrenergic receptor [Mus musculus]
MVLLSENASEGSNCTHPPAQVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAV
ADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ
RRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVV
AKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGSGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGC
FVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQ
SSKHALGYTLHPPSQAVEGQHRGMVRIPVGSGETFYKISKTDGVREWKFFSSMPQGSARITMPKDQSACT
TARVRSKSFLQVCCCVGSSTPRPEENHQVPTIKIHTISLGENGEEV

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Database Cross Reference

Ensembl Gene ENSMUST00000161339
ENSMUST00000159068
ENSMUST00000054661
UniGene Mm.57064
PDB
RefSeq NP_038489.2
Pfam PF00001