ceruloplasmin

General Information (Source: NCBI Gene,UniProt)

Text mining Term ceruloplasmin
UniProt ID CERU_RAT
Name Ferroxidase
Ceruloplasmin
Gene Names Cp
Taxonomy Rattus norvegicus

General annotation

Function Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. May also play a role in fetal lung development or pulmonary antioxidant defense.
Subcellular location Secreted.

Gene Ontology

GO:0005615 extracellular space CC
GO:0046658 anchored to plasma membrane CC
GO:0005507 copper ion binding MF
GO:0006879 cellular iron ion homeostasis BP
GO:0007584 response to nutrient BP
GO:0007568 aging BP
GO:0030324 lung development BP
GO:0046688 response to copper ion BP
GO:0004322 ferroxidase activity MF
GO:0015679 plasma membrane copper ion transport BP
GO:0001889 liver development BP

Sequence

>gi|6978695|ref|NP_036664.1| ceruloplasmin precursor [Rattus norvegicus]
MKFLLLSALLFLHSSLAWTREKHYYIGITEAVWDYASGSEEKELISVDTEQSNFYLRNGPDRIGRKYKKA
LYSEYTDGTFTKTIDKPAWLGFLGPVIKAEVGDKVSVHVKNFASRPYTFHAHGVTYTKANEGAIYPDNTT
DFQRADDKLFPGQQYLYVLRANEPSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLHKEKEE
NIDQEFVLMFSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSMCAEDRV
KWYLFGMGNEVDVHSELFHGQALTSKNYHTDIINLFPATLIDVSMVAQNPGVWMLSCQNLNHLKAGLQAF
FQVRDCNKPSPDDDIQDRHVRHYYIAAEETIWDYAPSGTDTFTGENFTSLGSDSRVFFEQGATRIGGSYK
KLVYREYTDDSFTNRKERGPDEEHLGILGPVIWAEVGDIIRVTFHNKGQFPLSIQPMGVRFTKENEGTYY
GPDGRSSKQASHVAPKETFTYEWTVPKEMGPTYADPVCLSKMYYSGVDLTKDIFTGLIGPMKICKKGSLL
ADGRQKDVDKEFYLFATVFDENESLLLDDNIRMFTTAPENVDKEDEDFQESNKMHSMNGFMYGNLPGLNM
CLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRDTANLFPHKSLTLLMTPDTEGSFDVECLTTDHYT
GGMKQKYTVNQCKGQFEDVTLYQGERTYYIAAVEVEWDYSPSRDWEMELHHLQEQNVSNAFLDKEEFFIG
SKYKKVVYREFTDSTFREQVKRRAEEEHLGMLGPLIHADVGAKVKVVFKNMATRPYSIHAHGVKTKSSTV
APTLPGEVRTYIWQIPERSGAGTEDSPCIPWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFNPKKKMEF
SLLFLVFDENESWYLDDNINTYPDHPEKDNKDNEEFIESNKMHAINGKMFGNLQGLTMHVGDEVNWYVMA
MGNEIDLHTVHFHGHSFQYKHRGIHSSDVFDFFPGTYQTLEMFPQTPGTWLLHCHVTDHIHAGMVTTYTV
LPNQETKSG

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.32777
PDB
RefSeq NP_036664.1
Pfam PF07731
PF00394
PF07732