calpain inhibitor

General Information (Source: NCBI Gene,UniProt)

Text mining Term calpain inhibitor
UniProt ID ICAL_RAT
Name Calpain inhibitor
Calpastatin
Gene Names Cast
Taxonomy Rattus norvegicus

General annotation

Function Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Subcellular location

Gene Ontology

GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity MF

Sequence

>gi|76159291|ref|NP_001028888.1| calpastatin isoform c [Rattus norvegicus]
MSRPGPKPAASSRPRRGAAASHTQEHVNEKNIGSSSKPAEKKGSDEVTASSAATGTSPRMSTTGAKAVKI
ESEKSQSSEPPVIHEKKPKGKPKEGSETKFQDAPSADGESVAGGVTVATASDKVVVKSGVNAALDDLIDT
LGECEDTNKDDPPYTGPVVLDPMDSTYLEALGIKEGTIPPEYRKLLEKNEAITGPLPDSPKPMGIDHAID
ALSSDFTCSSPTGKQTEKEKSTGESSKAQSAGVTRSAVPPQEKKRKVEEEVMNDQALQALSDSLGTRQPD
PQSHLRQAKQVKEAKAKEERQEKCGEDEDTVPAEYRLKPAKDKDGKPLLPEPEETSKCLSESELIGELSA
DFVQPTYQEKPSMPAAKIKKGVVPDDAVETLARSLGTRKEDPEDEKSLVDKVKEKAKEEDHEKLGEKEET
IPPDYRLEIVKDKDGKPLLPKEAEEQLPPLSDDFLLDALSQDFSSPANILSLGFEDAKLSAAVSETVSQV
PAPSNHTAAPPPGTERRDKELDDALDELSDSLGQRQPDPDENKPLDDKVKEKIKAEHSEKLGERDDTIPP
EYRHLLDNDGKDKPEKPLTKNTEKPGQDQDPIDALSEDLDSCPPTTETSQNTTKEKGKKTSSSKASKNEE
KTKDSSKKTEEVPKPKVDEDAT

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000062054
UniGene Rn.17481
PDB 3BOW
3DF0
RefSeq NP_445747.2
NP_001028887.1
NP_001028888.1
Pfam PF00748