vesicular glutamate transporter 3

General Information (Source: NCBI Gene,UniProt)

Text mining Term vesicular glutamate transporter 3
UniProt ID VGLU3_MOUSE
Name VGluT3
Vesicular glutamate transporter 3
Solute carrier family 17 member 8
Gene Names Slc17a8
Synonyms:Vglut3
Taxonomy Mus musculus

General annotation

Function Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
Subcellular location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome (By similarity).

Gene Ontology

GO:0005313 L-glutamate transmembrane transporter activity MF
GO:0016021 integral to membrane CC
GO:0030054 cell junction CC
GO:0006814 sodium ion transport BP
GO:0015293 symporter activity MF
GO:0019717 synaptosome CC
GO:0030672 synaptic vesicle membrane CC
GO:0007605 sensory perception of sound BP
GO:0006836 neurotransmitter transport BP

Sequence

>gi|33695072|ref|NP_892004.1| vesicular glutamate transporter 3 [Mus musculus]
MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTNEEEDAIELNEEGRPVQTSRAHRPVCDCSCC
GIPKRYICDCSCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPE
TVGLIHGSFFWGYIVTQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYGCVMGVRILQGLVEG
VTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLL
QAYECPAAHPTISNAERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQ
PAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVV
GFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTR
EEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLSEDKCGIIDQDELAEETELNHETFVSPRKKMS
YGATTQNCEVQKTEWRQQRESAFDGEEPLSYQAEGDFSETS

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Database Cross Reference

Ensembl Gene ENSMUST00000020102
UniGene Mm.233921
PDB
RefSeq NP_892004.1
Pfam PF07690