vesicular glutamate transporter 3

General Information (Source: NCBI Gene,UniProt)

Text mining Term vesicular glutamate transporter 3
UniProt ID VGLU3_RAT
Name Solute carrier family 17 member 8
VGluT3
Vesicular glutamate transporter 3
Gene Names Slc17a8
Synonyms:Vglut3
Taxonomy Rattus norvegicus

General annotation

Function Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
Subcellular location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome.

Gene Ontology

GO:0015293 symporter activity MF
GO:0007605 sensory perception of sound BP
GO:0006836 neurotransmitter transport BP
GO:0030054 cell junction CC
GO:0006814 sodium ion transport BP
GO:0030672 synaptic vesicle membrane CC
GO:0019717 synaptosome CC
GO:0016021 integral to membrane CC

Sequence

>gi|24308484|ref|NP_714947.1| vesicular glutamate transporter 3 [Rattus norvegicus]
MPFNAFDTFKEKILKPGKEGVKNAVGDSLGILQRKLDGTNEEGDAIELSEEGRPVQTSRARAPVCDCSCC
GIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGY
IVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKW
APPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAVHPTIS
NEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAIS
KVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFL
VLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALV
HYSGVIFYGVFASGEKQDWADPENLSEEKCGIIDQDELAEETELNHEAFVSPRKKMSYGATTQNCEVQKT
DRRQQRESAFEGEEPLSYQNEEDFSETS

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Database Cross Reference

Ensembl Gene ENSRNOT00000010207
UniGene Rn.84876
PDB
RefSeq NP_714947.1
Pfam PF07690