5 HT1A

General Information (Source: NCBI Gene,UniProt)

Text mining Term 5 HT1A
UniProt ID 5HT1A_RAT
Name 5-hydroxytryptamine receptor 1A
5-HT1A
5-HT-1A
Serotonin receptor 1A
Gene Names Htr1a
Synonyms:5ht1a
Taxonomy Rattus norvegicus

General annotation

Function This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0007198 inhibition of adenylate cyclase activity by serotonin receptor signaling pathway BP
GO:0043203 axon hillock CC
GO:0008144 drug binding MF
GO:0005886 plasma membrane CC
GO:0016021 integral to membrane CC
GO:0060259 regulation of feeding behavior BP
GO:0004993 serotonin receptor activity MF
GO:0051378 serotonin binding MF

Sequence

>gi|6981054|ref|NP_036717.1| 5-hydroxytryptamine receptor 1A [Rattus norvegicus]
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNV
ANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITD
PIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLL
MLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGA
VRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGII
MGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR

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Database Cross Reference

Ensembl Gene
UniGene Rn.44486
PDB
RefSeq NP_036717.1
Pfam PF00001