cholecystokinin

General Information (Source: NCBI Gene,UniProt)

Text mining Term cholecystokinin
UniProt ID CCKN_RAT
Name CCK8
Cholecystokinin-39
Cholecystokinin-12
CCK39
Cholecystokinin
CCK22
CCK12
CCK33
Cholecystokinin-33
CCK
Cholecystokinin-8
Cholecystokinin-22
Gene Names Cck
Taxonomy Rattus norvegicus

General annotation

Function This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Subcellular location Secreted.

Gene Ontology

GO:0008284 positive regulation of cell proliferation BP
GO:0043203 axon hillock CC
GO:0007409 axonogenesis BP
GO:0043194 initial segment CC
GO:0005615 extracellular space CC
GO:0043065 positive regulation of apoptotic process BP
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation BP
GO:0032099 negative regulation of appetite BP
GO:0001662 behavioral fear response BP
GO:0032461 positive regulation of protein oligomerization BP
GO:0042755 eating behavior BP
GO:0001764 neuron migration BP
GO:0030425 dendrite CC
GO:0001836 release of cytochrome c from mitochondria BP
GO:0006919 activation of caspase activity BP
GO:0051901 positive regulation of mitochondrial depolarization BP
GO:0005184 neuropeptide hormone activity MF
GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway BP
GO:0051930 regulation of sensory perception of pain BP
GO:0043195 terminal button CC
GO:0043204 perikaryon CC

Sequence

>gi|6978613|ref|NP_036961.1| cholecystokinin preproprotein [Rattus norvegicus]
MKCGVCLCVVMAVLAAGALAQPVVPVEAVDPMEQRAEEAPRRQLRAVLRPDSEPRARLGALLARYIQQVR
KAPSGRMSVLKNLQGLDPSHRISDRDYMGWMDFGRRSAEDYEYPS

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000026159
UniGene Rn.9781
PDB
RefSeq NP_036961.1
Pfam PF00918