PAFR

General Information (Source: NCBI Gene,UniProt)

Text mining Term PAFR
UniProt ID PTAFR_RAT
Name PAF-R
Platelet-activating factor receptor
PAFr
Gene Names Ptafr
Taxonomy Rattus norvegicus

General annotation

Function Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0005886 plasma membrane CC
GO:0006935 chemotaxis BP
GO:0016021 integral to membrane CC

Sequence

>gi|16758018|ref|NP_445773.1| platelet-activating factor receptor [Rattus norvegicus]
MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTL
PLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLV
IWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVII
HTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCL
LSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000017687
UniGene Rn.10137
PDB
RefSeq NP_445773.1
Pfam PF00001