nestin

General Information (Source: NCBI Gene,UniProt)

Text mining Term nestin
UniProt ID NEST_MOUSE
Name Nestin
Gene Names Nes
Taxonomy Mus musculus

General annotation

Function Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division (By similarity). Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.
Subcellular location

Gene Ontology

GO:0007420 brain development BP
GO:2000179 positive regulation of neural precursor cell proliferation BP
GO:0043066 negative regulation of apoptotic process BP
GO:0031076 embryonic camera-type eye development BP
GO:0030844 positive regulation of intermediate filament depolymerization BP
GO:0005882 intermediate filament CC
GO:0019215 intermediate filament binding MF
GO:0048858 cell projection morphogenesis BP
GO:0005737 cytoplasm CC
GO:0005198 structural molecule activity MF

Sequence

>gi|50363232|ref|NP_057910.3| nestin [Mus musculus]
MEGCVGEESFQMWELNRRLEAYLTRVKTLEEQNQLLSAELGGLRAQSGDASWRARADDELAALRVLVDQR
WREKHEAEVQRDNLAEELESVAGRCQQVRLARERTIEEAACSRRALEAEKNARGWLSTQAAELERELEAL
RASHEEERAHLNAQAACTPRRPPAPAHASPIRAPEVEELARRLGEVWRGAVRDYQERVAHMESSLGQARE
RLGQAVRGARESRLEVQQLQADRDSLQERREALEQRLEGRWQDRLQATEKFQLAVEALEQEKQGLQSQIA
QILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRSSQASLGFPDPKLKLHFLGIPEDQHLGSVLP
VLSPTSFSSPLPNTLETPVTAFLKTQEFLKARTPTLASTPIPPMSEAPYPKNAEVRAQDVPHSLLQGGRQ
QAPEPLWAEATVPSSTGVLPELEEPGGEQPDHFPDDPTSLAPPLNPHHSILEAKDRESSESRVSSIFQEE
EGQIWELVKKEAATEVKVENSLAQEIQESGLDTEEIQDSQGPLQMETLEALGDEPLMSLKTQNHETPGKE
NCNSSIEENSGTVKSPEKEKQTPLKSLEEKNVEAEKTLENGVLELSKPLGEEEPRMEDQELMSPEHTLET
VSFLGKENQEVVRSSEEQNLESLITFKEESQYPLGGPEAEDQMLERLVEKEDQRFPRSPEEDQQAFRPLE
KENQEPLRFEEAEDQVLERLIEKERQESLKSPEEEDQQAFRLLEKENQEPLRFEDAEDQVLERLIEKERQ
ESLKSPEEEDQQAFRLLEKENQEPLRFEEAEDQVLERLVEKESQESLKSPEEEDQRTGKPLEKENQESLR
SLDENQETIVLLESKNQRPLRSLEVEEEEQRIVKPLEKVSQVSLESLEKENVQSPRYLEEDDHMIKSLLE
DKTHEILGSLEDRNGENFIPPENETQGSLRPPEEEDQRIVNHLEKESQEFLRSPEAEEEEEQVMVRSLEG
ENHDPLSSVVKEEQMAESKLENESQDSRKSLEDESQETFGSLEKENLESLRSLAGQDQEEQKLEQETQQP
LRAVEDEQMTVNPPEKVDPELPKPLRNDQEVVRSLDKENQESLVSLNEGGMETVKSSETENIESLETVGE
CLGRRKSVDTQEPLWSTEVTSETIEPLEDETQEPLGCVDENQEVLTPLERESQELRSLGKWNPETVESPG
GVEDSQQCLEVEEGPEREQHQESLRSLGEVEWELPGSGSQQRWEDVVEDGEGQEASLGATGVETEDKAEL
HLRGQGGEEKAVEEGELLQDAVGEAWSLGSSEPKEQRVPAEPLDDLEGQPEQTGTLEVPVAQGMPEATEQ
DEDRAQAGEQDSVEVTLGLEAARAGLELEQEVVGLEDPRHFAREEAIHPSLGEESVKAKIDQGLEEPGKE
PKEAGALDSGIPELPKTSSETLECKGWEESGEGWGEEEASLETSDHEGSHAPQPRPPKTEEDEGLQAALT
VPGPKLLEPCSPIPILTDAHELQPQAEGIQEAGWQPEAGTEALGRVEDEPEFGRGEIPEGLQDWEEGRED
SEADELGETLPDSTPLGLYLKSPASPKWEQAGEQRLFPQGEARKEGWSPAALAAQGLSDPPEEEQQGHDS
DLSSEEFEDLGTEASLLPGVPKEVSDHLGQEPPVLQPACWDQGGESDGFADEEESGEEGEEEDADEEEGA
ESGTQWWGPGPSGGGVKVQDVTQRGDLEHESVGDSGLWDDGLSGAAANVLVTALETVSQDSAEPSGSEGS
ESASLEGEEGQAIDHLDAPQEVTSVVPGAGDTFDISGQGPNLESEQVNGRMENGLEQAEGQVVLHGDEDQ
GIPLQEQGTLKAPLVGSPVHLGPSQPLKFTLSGVDGDSWSSGED

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000160694
ENSMUST00000090973
UniGene Mm.331129
PDB
RefSeq NP_057910.3
Pfam PF00038