Vesicular glutamate transporter 2

General Information (Source: NCBI Gene,UniProt)

Text mining Term Vesicular glutamate transporter 2
UniProt ID VGLU2_MOUSE
Name Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
Solute carrier family 17 member 6
VGluT2
Vesicular glutamate transporter 2
Differentiation-associated BNPI
Gene Names Slc17a6
Taxonomy Mus musculus

General annotation

Function Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
Subcellular location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome.

Gene Ontology

GO:0001504 neurotransmitter uptake BP
GO:0016021 integral to membrane CC
GO:0006814 sodium ion transport BP
GO:0030054 cell junction CC
GO:0019717 synaptosome CC
GO:0015293 symporter activity MF
GO:0005313 L-glutamate transmembrane transporter activity MF
GO:0030672 synaptic vesicle membrane CC

Sequence

>gi|188219544|ref|NP_543129.3| vesicular glutamate transporter 2 [Mus musculus]
MESVKQRILAPGKEGIKNFAGKSLGQIYRVLEKKQDNRETIELTEDGKPLEVPEKKAPLCDCTCFGLPRR
YIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQI
PGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLE
RSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERR
YIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGM
LSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAV
GFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGG
VIFYALFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATSQENGGWPNGWEK
KEEFVQEGAQDAYTYKDRDDYS

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Database Cross Reference

Ensembl Gene ENSMUST00000032710
UniGene Mm.256618
PDB
RefSeq NP_543129.3
Pfam PF07690