Vesicular glutamate transporter 2

General Information (Source: NCBI Gene,UniProt)

Text mining Term Vesicular glutamate transporter 2
UniProt ID VGLU2_RAT
Name Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
Differentiation-associated BNPI
Vesicular glutamate transporter 2
VGluT2
Solute carrier family 17 member 6
Gene Names Slc17a6
Taxonomy Rattus norvegicus

General annotation

Function Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. May also mediate the transport of inorganic phosphate.
Subcellular location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome.

Gene Ontology

GO:0016021 integral to membrane CC
GO:0006814 sodium ion transport BP
GO:0001504 neurotransmitter uptake BP
GO:0005313 L-glutamate transmembrane transporter activity MF
GO:0019717 synaptosome CC
GO:0030054 cell junction CC
GO:0015293 symporter activity MF
GO:0005769 early endosome CC
GO:0030672 synaptic vesicle membrane CC

Sequence

>gi|16758166|ref|NP_445879.1| vesicular glutamate transporter 2 [Rattus norvegicus]
MESVKQRILAPGKEGIKNFAGKSLGQIYRVLEKKQDNRETIELTEDGKPLEVPEKKAPLCDCTCFGLPRR
YIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQI
PGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLE
RSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERR
YIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGM
LSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAV
GFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGG
VIFYALFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATSQENGGWPNGWEK
KEEFVQESAQDAYSYKDRDDYS

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Database Cross Reference

Ensembl Gene
UniGene Rn.19372
PDB
RefSeq NP_445879.1
Pfam PF07690